This is sure simple if you follow the guide but it took a lot of hacking around to make this work on Debian/Ubuntu! Now before you ask why bother running wine and python, the reason is because Python executables are NOT cross-platform. If you run pyinstaller in Linux, that binary will only run on Linux and the same if you do it in Windows. So it is preferable if you have a single environment that you can create Linux and Windows binaries from rather than running 2 separate........

After an upgrade wine wouldn't open anything, not even the pre-installed notepad. There are no wine logs and nothing is mentioned in any standard log file about why. I finally decided to run wine from the shell and see what's going on: wine client error:0: version mismatch 398/402. Your wineserver binary was not upgraded correctly, or you have an older one somewhere in your PATH. Or maybe the wrong wineserver is still running?........