2,6,A or E is what the second digit of your MAC address must be otherwise a lot of OS's will not work. They will say the NIC is down/not connected even though it is.
This is because if the second digit is not set properly it will not view as a valid MAC or device uplink. This is especially an issue with VMs whether in QEMU etc.. if you are making your own MAC.
MAC address is invalid
c4:d1:aa:e5:10:05
To fix it just change the c4 to c2, c6, ca or ce
MAC address is valid / correct
42:b9:4d:81:59:3c
46:b9:4d:81:59:3c
4a:b9:4d:81:59:3c
4e:b9:4d:81:59:3c
vs, universally, administered, nic, refuses, digit, os, valid, uplink, vms, qemu, etc, invalid, aa, ca, ce,